{"id":235810,"date":"2026-04-23T22:27:51","date_gmt":"2026-04-24T03:27:51","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/abstract-proposing-a-no-nonsense-strategy-for-the-treatment-of-dominant-neurodevelopmental-disorders"},"modified":"2026-04-23T22:27:51","modified_gmt":"2026-04-24T03:27:51","slug":"abstract-proposing-a-no-nonsense-strategy-for-the-treatment-of-dominant-neurodevelopmental-disorders","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/abstract-proposing-a-no-nonsense-strategy-for-the-treatment-of-dominant-neurodevelopmental-disorders","title":{"rendered":"Abstract: Proposing a no-nonsense strategy for the treatment of dominant neurodevelopmental disorders:"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/abstract131.jpg\"><\/a><\/p>\n<p>Xiaochang Zhang &amp; team introduce exon annotation for nonsense-mediated mRNA (EANMD) and report on alternatively spliced exons in the brain that trigger mRNA decay, noting modulation of such exons in disease-causal genes can potentially treat neurodevelopmental disorders.<\/p>\n<hr>\n<p>Address correspondence to: Xiaochang Zhang, University of Chicago, Cummings Life <i>Science<\/i> Center 507A, 920 E. 58th St., Chicago, Illinois 60,637, USA. Phone: 773.834.5369; Email: <a href=\"mailto:xczhang@uchicago.edu.\">xczhang@uchicago.edu.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Xiaochang Zhang &amp; team introduce exon annotation for nonsense-mediated mRNA (EANMD) and report on alternatively spliced exons in the brain that trigger mRNA decay, noting modulation of such exons in disease-causal genes can potentially treat neurodevelopmental disorders. Address correspondence to: Xiaochang Zhang, University of Chicago, Cummings Life Science Center 507A, 920 E. 58th St., Chicago, [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1512,47],"tags":[],"class_list":["post-235810","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-mobile-phones","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235810","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=235810"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235810\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=235810"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=235810"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=235810"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}