{"id":235785,"date":"2026-04-23T18:15:07","date_gmt":"2026-04-23T23:15:07","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/cav3-1-is-a-neuronal-leucine-sensor-that-mediates-satiety-and-weight-loss-in-response-to-dietary-protein"},"modified":"2026-04-23T18:15:07","modified_gmt":"2026-04-23T23:15:07","slug":"cav3-1-is-a-neuronal-leucine-sensor-that-mediates-satiety-and-weight-loss-in-response-to-dietary-protein","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/cav3-1-is-a-neuronal-leucine-sensor-that-mediates-satiety-and-weight-loss-in-response-to-dietary-protein","title":{"rendered":"Cav3.1 is a neuronal leucine sensor that mediates satiety and weight loss in response to dietary protein"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/cav3-1-is-a-neuronal-leucine-sensor-that-mediates-satiety-and-weight-loss-in-response-to-dietary-protein2.jpg\"><\/a><\/p>\n<p>Online now: Tsang et al. identify the T-type calcium channel Cav3.1 as a neuronal leucine sensor in hypothalamic POMC neurons. Leucine directly binds Cav3.1, lowering its activation threshold. Loss of Cav3.1 in POMC neurons abolishes high-protein diet-induced appetite suppression, while pharmacological activation promotes weight loss and potentiates the effects of anorectic agents.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Online now: Tsang et al. identify the T-type calcium channel Cav3.1 as a neuronal leucine sensor in hypothalamic POMC neurons. Leucine directly binds Cav3.1, lowering its activation threshold. Loss of Cav3.1 in POMC neurons abolishes high-protein diet-induced appetite suppression, while pharmacological activation promotes weight loss and potentiates the effects of anorectic agents.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1694,47],"tags":[],"class_list":["post-235785","post","type-post","status-publish","format-standard","hentry","category-electronics","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235785","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=235785"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235785\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=235785"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=235785"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=235785"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}