{"id":235779,"date":"2026-04-23T14:24:24","date_gmt":"2026-04-23T19:24:24","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/autoinhibitory-control-of-mlkl-governs-pseudokinase-domain-phosphorylation-and-oligomerization-during-necroptosis"},"modified":"2026-04-23T14:24:24","modified_gmt":"2026-04-23T19:24:24","slug":"autoinhibitory-control-of-mlkl-governs-pseudokinase-domain-phosphorylation-and-oligomerization-during-necroptosis","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/autoinhibitory-control-of-mlkl-governs-pseudokinase-domain-phosphorylation-and-oligomerization-during-necroptosis","title":{"rendered":"Autoinhibitory control of MLKL governs pseudokinase domain phosphorylation and oligomerization during necroptosis"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/autoinhibitory-control-of-mlkl-governs-pseudokinase-domain-phosphorylation-and-oligomerization-during-necroptosis2.jpg\"><\/a><\/p>\n<p>The current model of necroptosis assumes that MLKL\u2019s N-terminal cytotoxic domain is unleashed from autoinhibition concurrent with phosphorylation by RIPK3. Here, Pan and Abbott show that inhibition of MLKL\u2019s N terminus abolishes phosphorylation by RIPK3 whereas removal or relieving autoinhibition between the N-terminal and intermediate domains promotes its phosphorylation.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The current model of necroptosis assumes that MLKL\u2019s N-terminal cytotoxic domain is unleashed from autoinhibition concurrent with phosphorylation by RIPK3. Here, Pan and Abbott show that inhibition of MLKL\u2019s N terminus abolishes phosphorylation by RIPK3 whereas removal or relieving autoinhibition between the N-terminal and intermediate domains promotes its phosphorylation.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-235779","post","type-post","status-publish","format-standard","hentry","category-futurism"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235779","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=235779"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235779\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=235779"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=235779"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=235779"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}