{"id":235721,"date":"2026-04-22T22:13:52","date_gmt":"2026-04-23T03:13:52","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/fecal-microbiota-transplant-and-multidrug-resistant-organism-decolonization-in-gastrointestinal-disease-a-randomized-clinical-trial"},"modified":"2026-04-22T22:13:52","modified_gmt":"2026-04-23T03:13:52","slug":"fecal-microbiota-transplant-and-multidrug-resistant-organism-decolonization-in-gastrointestinal-disease-a-randomized-clinical-trial","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/fecal-microbiota-transplant-and-multidrug-resistant-organism-decolonization-in-gastrointestinal-disease-a-randomized-clinical-trial","title":{"rendered":"Fecal Microbiota Transplant and Multidrug-Resistant Organism Decolonization in Gastrointestinal Disease: A Randomized Clinical Trial"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/fecal-microbiota-transplant-and-multidrug-resistant-organism-decolonization-in-gastrointestinal-disease-a-randomized-clinical-trial2.jpg\"><\/a><\/p>\n<p>A randomized clinical trial evaluated if fecal microbiota transplant (FMT) is effective in achieving gut decolonization of multidrug-resistant organisms (MDROs) and reducing antimicrobial resistance (AMR) gene abundance in patients with gastrointestinal (GI) diseases.<\/p>\n<p>Among 114 adults, a single FMT session did not significantly increase rates of MDRO decolonization or reduce antimicrobial resistance gene abundance compared to sham intervention. However, FMT was associated with increased bacterial diversity and enrichment with bacteria capable of producing short-chain fatty acids. No significant safety concerns were observed.<\/p>\n<p>These findings indicate that while a single FMT session does not support routine use for MDRO decolonization in GIDisease, microbiome changes warrant further research.<\/p>\n<hr>\n<p>This randomized clinical trial assesses the efficacy of fecal microbiota transplant in causing multidrug-resistant organism decolonization and decreasing antimicrobial resistance genes in patients with gastrointestinal diseases.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A randomized clinical trial evaluated if fecal microbiota transplant (FMT) is effective in achieving gut decolonization of multidrug-resistant organisms (MDROs) and reducing antimicrobial resistance (AMR) gene abundance in patients with gastrointestinal (GI) diseases. Among 114 adults, a single FMT session did not significantly increase rates of MDRO decolonization or reduce antimicrobial resistance gene abundance compared [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-235721","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235721","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=235721"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235721\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=235721"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=235721"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=235721"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}