{"id":235720,"date":"2026-04-22T22:13:06","date_gmt":"2026-04-23T03:13:06","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/a-skin-hypothalamus-axis-couples-heat-stress-and-metabolic-dysfunction"},"modified":"2026-04-22T22:13:06","modified_gmt":"2026-04-23T03:13:06","slug":"a-skin-hypothalamus-axis-couples-heat-stress-and-metabolic-dysfunction","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/a-skin-hypothalamus-axis-couples-heat-stress-and-metabolic-dysfunction","title":{"rendered":"A skin-hypothalamus axis couples heat stress and metabolic dysfunction"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/a-skin-hypothalamus-axis-couples-heat-stress-and-metabolic-dysfunction2.jpg\"><\/a><\/p>\n<p>Now online! Heat stress activates a skin-hypothalamus axis via KLK14-dependent epigenetic reprogramming of LRRC7\u207a astrocytes, thereby exacerbating diet-induced metabolic dysfunction. Vitamin A reduces KLK14 levels and mitigates metabolic impairment in both mice and humans.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Now online! Heat stress activates a skin-hypothalamus axis via KLK14-dependent epigenetic reprogramming of LRRC7\u207a astrocytes, thereby exacerbating diet-induced metabolic dysfunction. Vitamin A reduces KLK14 levels and mitigates metabolic impairment in both mice and humans.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[412],"tags":[],"class_list":["post-235720","post","type-post","status-publish","format-standard","hentry","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235720","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=235720"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235720\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=235720"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=235720"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=235720"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}