{"id":235713,"date":"2026-04-22T18:13:29","date_gmt":"2026-04-22T23:13:29","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/activation-of-the-nlrp3-inflammasome-in-osteoclasts-is-suppressed-by-a-tmem178-dependent-mechanism-that-restricts-ca2-influx"},"modified":"2026-04-22T18:13:29","modified_gmt":"2026-04-22T23:13:29","slug":"activation-of-the-nlrp3-inflammasome-in-osteoclasts-is-suppressed-by-a-tmem178-dependent-mechanism-that-restricts-ca2-influx","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/activation-of-the-nlrp3-inflammasome-in-osteoclasts-is-suppressed-by-a-tmem178-dependent-mechanism-that-restricts-ca2-influx","title":{"rendered":"Activation of the NLRP3 inflammasome in osteoclasts is suppressed by a Tmem178-dependent mechanism that restricts Ca2+ influx"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/activation-of-the-nlrp3-inflammasome-in-osteoclasts-is-suppressed-by-a-tmem178-dependent-mechanism-that-restricts-ca2-influx2.jpg\"><\/a><\/p>\n<p>Researchers have uncovered a pathway that keeps bone resorption in check by dampening the activation of inflammasomes in osteoclasts\u2014identifying an important restraint and helping to answer a paradox in the field of bone biology.<\/p>\n<p>Learn more in <i>Science <\/i>Signaling.<\/p>\n<hr>\n<p>The ER protein <i>Tmem178<\/i> prevents bone loss by limiting Ca2+-dependent inflammasome activation in osteoclasts.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers have uncovered a pathway that keeps bone resorption in check by dampening the activation of inflammasomes in osteoclasts\u2014identifying an important restraint and helping to answer a paradox in the field of bone biology. Learn more in Science Signaling. The ER protein Tmem178 prevents bone loss by limiting Ca2+-dependent inflammasome activation in osteoclasts.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-235713","post","type-post","status-publish","format-standard","hentry","category-biological"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235713","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=235713"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235713\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=235713"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=235713"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=235713"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}