{"id":235700,"date":"2026-04-22T11:45:11","date_gmt":"2026-04-22T16:45:11","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/cellular-and-molecular-landscapes-of-human-tendons-across-the-lifespan-revealed-by-spatial-and-single-cell-transcriptomics"},"modified":"2026-04-22T11:45:11","modified_gmt":"2026-04-22T16:45:11","slug":"cellular-and-molecular-landscapes-of-human-tendons-across-the-lifespan-revealed-by-spatial-and-single-cell-transcriptomics","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/cellular-and-molecular-landscapes-of-human-tendons-across-the-lifespan-revealed-by-spatial-and-single-cell-transcriptomics","title":{"rendered":"Cellular and molecular landscapes of human tendons across the lifespan revealed by spatial and single-cell transcriptomics"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/cellular-and-molecular-landscapes-of-human-tendons-across-the-lifespan-revealed-by-spatial-and-single-cell-transcriptomics.jpg\"><\/a><\/p>\n<p>Kurjan et al. map human tendon architecture from embryo to adult using spatial and single-cell transcriptomics. They show embryonic progenitors generate fibrillar, connective, and chondrogenic tendon lineages. Fibroblasts reprogram with age, whereas immune, vascular, and neural cells remain stable. Ruptured adult tendons partially reactivate fetal programs without full regeneration.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Kurjan et al. map human tendon architecture from embryo to adult using spatial and single-cell transcriptomics. They show embryonic progenitors generate fibrillar, connective, and chondrogenic tendon lineages. Fibroblasts reprogram with age, whereas immune, vascular, and neural cells remain stable. Ruptured adult tendons partially reactivate fetal programs without full regeneration.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-235700","post","type-post","status-publish","format-standard","hentry","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235700","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=235700"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235700\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=235700"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=235700"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=235700"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}