{"id":235654,"date":"2026-04-21T18:14:51","date_gmt":"2026-04-21T23:14:51","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/the-autoantigen-trim21-assembles-proinflammatory-immune-complexes-after-lytic-cell-death"},"modified":"2026-04-21T18:14:51","modified_gmt":"2026-04-21T23:14:51","slug":"the-autoantigen-trim21-assembles-proinflammatory-immune-complexes-after-lytic-cell-death","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/the-autoantigen-trim21-assembles-proinflammatory-immune-complexes-after-lytic-cell-death","title":{"rendered":"The autoantigen TRIM21 assembles proinflammatory immune complexes after lytic cell death"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/the-autoantigen-trim21-assembles-proinflammatory-immune-complexes-after-lytic-cell-death2.jpg\"><\/a><\/p>\n<p>Proinflammatory lytic cell death releases cytosolic TRIM21, which binds to circulating antibodies and is internalized by macrophages, stimulating cross-antigen presentation and inflammation in Sj\u00f6gren\u2019s disease.<\/p>\n<p>Learn more in <i>Science <\/i>Immunology.<\/p>\n<hr>\n<p>TRIM21\/Ro52 assembles proinflammatory immune complexes.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Proinflammatory lytic cell death releases cytosolic TRIM21, which binds to circulating antibodies and is internalized by macrophages, stimulating cross-antigen presentation and inflammation in Sj\u00f6gren\u2019s disease. Learn more in Science Immunology. TRIM21\/Ro52 assembles proinflammatory immune complexes.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-235654","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235654","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=235654"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235654\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=235654"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=235654"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=235654"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}