{"id":235640,"date":"2026-04-21T06:08:08","date_gmt":"2026-04-21T11:08:08","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/aberrant-multicellular-interferon-signaling-underlies-adar1-mutation-driven-aicardi-goutieres-syndrome-like-encephalopathy"},"modified":"2026-04-21T06:08:08","modified_gmt":"2026-04-21T11:08:08","slug":"aberrant-multicellular-interferon-signaling-underlies-adar1-mutation-driven-aicardi-goutieres-syndrome-like-encephalopathy","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/aberrant-multicellular-interferon-signaling-underlies-adar1-mutation-driven-aicardi-goutieres-syndrome-like-encephalopathy","title":{"rendered":"Aberrant multicellular interferon signaling underlies Adar1 mutation\u2013driven Aicardi-Gouti\u00e8res syndrome-like encephalopathy"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/aberrant-multicellular-interferon-signaling-underlies-adar1-mutation-driven-aicardi-goutieres-syndrome-like-encephalopathy2.jpg\"><\/a><\/p>\n<p>Yoo et al. demonstrate that Z-RNA binding-deficient ADAR1 triggers aberrant multicellular type I interferon production, especially from astrocytes, and induces marked periventricular encephalopathy in mice. Blocking type I interferon signaling fully rescues the pathology, indicating that ventricular accumulation of type I interferon is the central driver of periventricular encephalopathy.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Yoo et al. demonstrate that Z-RNA binding-deficient ADAR1 triggers aberrant multicellular type I interferon production, especially from astrocytes, and induces marked periventricular encephalopathy in mice. Blocking type I interferon signaling fully rescues the pathology, indicating that ventricular accumulation of type I interferon is the central driver of periventricular encephalopathy.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-235640","post","type-post","status-publish","format-standard","hentry","category-futurism"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235640","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=235640"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235640\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=235640"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=235640"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=235640"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}