{"id":235536,"date":"2026-04-20T01:18:52","date_gmt":"2026-04-20T06:18:52","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/b-cell-deficiency-limits-exercise-capacity-by-remodeling-liver-glutamate-metabolism"},"modified":"2026-04-20T01:18:52","modified_gmt":"2026-04-20T06:18:52","slug":"b-cell-deficiency-limits-exercise-capacity-by-remodeling-liver-glutamate-metabolism","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/b-cell-deficiency-limits-exercise-capacity-by-remodeling-liver-glutamate-metabolism","title":{"rendered":"B cell deficiency limits exercise capacity by remodeling liver glutamate metabolism"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/b-cell-deficiency-limits-exercise-capacity-by-remodeling-liver-glutamate-metabolism2.jpg\"><\/a><\/p>\n<p>Now online! B cells regulate exercise capacity through immune-independent liver-muscle metabolic signaling, and B cell deficiency limits muscle performance. Mechanistically, B cell-secreted TGF-\u03b21 increases hepatic glutamine-to-glutamate conversion, raising glutamate in blood and muscle. This promotes muscle calcium signaling and mitochondrial function, positively regulating exercise capacity.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Now online! B cells regulate exercise capacity through immune-independent liver-muscle metabolic signaling, and B cell deficiency limits muscle performance. Mechanistically, B cell-secreted TGF-\u03b21 increases hepatic glutamine-to-glutamate conversion, raising glutamate in blood and muscle. This promotes muscle calcium signaling and mitochondrial function, positively regulating exercise capacity.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1495],"tags":[],"class_list":["post-235536","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-health"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235536","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=235536"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235536\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=235536"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=235536"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=235536"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}