{"id":235528,"date":"2026-04-19T10:06:55","date_gmt":"2026-04-19T15:06:55","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/long-term-outcomes-and-recovery-trajectories-in-out-of-hospital-cardiac-arrest-a-2-year-follow-up-of-the-randomized-clinical-ttm2-trial"},"modified":"2026-04-19T10:06:55","modified_gmt":"2026-04-19T15:06:55","slug":"long-term-outcomes-and-recovery-trajectories-in-out-of-hospital-cardiac-arrest-a-2-year-follow-up-of-the-randomized-clinical-ttm2-trial","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/long-term-outcomes-and-recovery-trajectories-in-out-of-hospital-cardiac-arrest-a-2-year-follow-up-of-the-randomized-clinical-ttm2-trial","title":{"rendered":"Long-Term Outcomes and Recovery Trajectories in Out-of-Hospital Cardiac Arrest: A 2-Year Follow-Up of the Randomized Clinical TTM2 Trial"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/long-term-outcomes-and-recovery-trajectories-in-out-of-hospital-cardiac-arrest-a-2-year-follow-up-of-the-randomized-clinical-ttm2-trial.png\"><\/a><\/p>\n<p>Following out-of-hospital cardiac arrest, targeted hypothermia did not affect societal participation or cognitive function at 24 months compared with normothermia; most recovery occurred within 6 months.<\/p>\n<hr>\n<p>Question Does hypothermia after out-of-hospital cardiac arrest affect societal participation or cognitive functioning at 24 months post arrest, and how do these outcomes evolve over time?<\/p>\n<p><strong>Findings<\/strong> This follow-up of the randomized clinical Targeted Hypothermia vs Targeted Normothermia After Out-of-Hospital Cardiac Arrest trial found no significant differences in societal participation or cognitive functioning between targeted hypothermia and normothermia at 24 months. Overall recovery was limited beyond 6 months.<\/p>\n<p><strong>Meaning<\/strong> Targeted hypothermia compared with normothermia did not affect outcomes 24 months post arrest, suggesting no longer-term effect of hypothermia for the explored outcomes; 6 months may suffice as an end point when assessing functional or cognitive outcomes after out-of-hospital cardiac arrest.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Following out-of-hospital cardiac arrest, targeted hypothermia did not affect societal participation or cognitive function at 24 months compared with normothermia; most recovery occurred within 6 months. Question Does hypothermia after out-of-hospital cardiac arrest affect societal participation or cognitive functioning at 24 months post arrest, and how do these outcomes evolve over time? Findings This follow-up [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-235528","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235528","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=235528"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235528\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=235528"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=235528"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=235528"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}