{"id":235360,"date":"2026-04-16T15:38:18","date_gmt":"2026-04-16T20:38:18","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/a-black-licorice-compound-slashes-gut-inflammation-and-cell-death-in-ibd-models-and-animals"},"modified":"2026-04-16T15:38:18","modified_gmt":"2026-04-16T20:38:18","slug":"a-black-licorice-compound-slashes-gut-inflammation-and-cell-death-in-ibd-models-and-animals","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/a-black-licorice-compound-slashes-gut-inflammation-and-cell-death-in-ibd-models-and-animals","title":{"rendered":"A black licorice compound slashes gut inflammation and cell death in IBD models and animals"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/a-black-licorice-compound-slashes-gut-inflammation-and-cell-death-in-ibd-models-and-animals2.jpg\"><\/a><\/p>\n<p>A <a href=\"https:\/\/www.cell.com\/stem-cell-reports\/fulltext\/S2213-6711(26)00102-5\" target=\"_blank\">new study<\/a> published in <i>Stem Cell Reports<\/i> demonstrates how a human stem cell-derived model of the intestine can be used to identify potential therapies for inflammatory bowel disease (IBD), highlighting glycyrrhizin as a promising candidate for reducing intestinal inflammation and cell death.<\/p>\n<p>The burden of IBD is rising globally, with an estimated 4 million people affected worldwide. The disease is characterized by chronic inflammation of the intestinal wall, leading to symptoms such as persistent diarrhea, abdominal pain, and fatigue. Standard treatments include anti-inflammatory drugs and other immune-targeting therapies, but many patients experience only limited benefit.<\/p>\n<p>High-throughput screening (HTS) offers a promising strategy to discover new IBD therapies but depends on having a reliable model of the human intestinal wall for laboratory testing.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new study published in Stem Cell Reports demonstrates how a human stem cell-derived model of the intestine can be used to identify potential therapies for inflammatory bowel disease (IBD), highlighting glycyrrhizin as a promising candidate for reducing intestinal inflammation and cell death. The burden of IBD is rising globally, with an estimated 4 million [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-235360","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235360","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=235360"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235360\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=235360"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=235360"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=235360"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}