{"id":235292,"date":"2026-04-15T22:23:07","date_gmt":"2026-04-16T03:23:07","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/spatiotemporal-molecular-profiling-of-macrophage-fibroblast-crosstalk-defines-checkpoints-orchestrating-onset-and-resolution-of-inflammation"},"modified":"2026-04-15T22:23:07","modified_gmt":"2026-04-16T03:23:07","slug":"spatiotemporal-molecular-profiling-of-macrophage-fibroblast-crosstalk-defines-checkpoints-orchestrating-onset-and-resolution-of-inflammation","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/spatiotemporal-molecular-profiling-of-macrophage-fibroblast-crosstalk-defines-checkpoints-orchestrating-onset-and-resolution-of-inflammation","title":{"rendered":"Spatiotemporal molecular profiling of macrophage-fibroblast crosstalk defines checkpoints orchestrating onset and resolution of inflammation"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/spatiotemporal-molecular-profiling-of-macrophage-fibroblast-crosstalk-defines-checkpoints-orchestrating-onset-and-resolution-of-inflammation2.jpg\"><\/a><\/p>\n<p>Weishaupt, Chambers, et al. combine single-cell transcriptomic and epigenomic profiling with <i>in vivo<\/i> models to map the temporal dynamics of macrophage-fibroblast communication during inflammatory arthritis. They show that fibroblasts initiate inflammation, whereas monocyte-derived macrophages undergo transcriptional reprogramming into SPP1+ cells that actively promote resolution by restraining fibroblast pathogenicity.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Weishaupt, Chambers, et al. combine single-cell transcriptomic and epigenomic profiling with in vivo models to map the temporal dynamics of macrophage-fibroblast communication during inflammatory arthritis. They show that fibroblasts initiate inflammation, whereas monocyte-derived macrophages undergo transcriptional reprogramming into SPP1+ cells that actively promote resolution by restraining fibroblast pathogenicity.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-235292","post","type-post","status-publish","format-standard","hentry","category-futurism"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235292","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=235292"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235292\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=235292"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=235292"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=235292"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}