{"id":235280,"date":"2026-04-15T18:20:33","date_gmt":"2026-04-15T23:20:33","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/aars1-mediated-lactylation-of-stat1-drives-immune-evasion"},"modified":"2026-04-15T18:20:33","modified_gmt":"2026-04-15T23:20:33","slug":"aars1-mediated-lactylation-of-stat1-drives-immune-evasion","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/aars1-mediated-lactylation-of-stat1-drives-immune-evasion","title":{"rendered":"AARS1-mediated lactylation of STAT1 drives immune evasion"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/aars1-mediated-lactylation-of-stat1-drives-immune-evasion2.jpg\"><\/a><\/p>\n<p>Du et al. demonstrate that AARS1-mediated STAT1 K193 lactylation blocks JAK2 binding and STAT1 phosphorylation, which impairs IFN-\u03b3 signaling, reducing chemokine expression and promoting immune escape. Inhibition of this modification with the cell-penetrating peptide K193-pe restores IFN-\u03b3 responsiveness, enhances CD8+ T cell recruitment, and improves immune checkpoint therapy efficacy.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Du et al. demonstrate that AARS1-mediated STAT1 K193 lactylation blocks JAK2 binding and STAT1 phosphorylation, which impairs IFN-\u03b3 signaling, reducing chemokine expression and promoting immune escape. Inhibition of this modification with the cell-penetrating peptide K193-pe restores IFN-\u03b3 responsiveness, enhances CD8+ T cell recruitment, and improves immune checkpoint therapy efficacy.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-235280","post","type-post","status-publish","format-standard","hentry","category-futurism"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235280","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=235280"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235280\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=235280"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=235280"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=235280"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}