{"id":235267,"date":"2026-04-15T14:30:33","date_gmt":"2026-04-15T19:30:33","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/activated-neutrophils-are-a-hallmark-of-acute-lung-injury"},"modified":"2026-04-15T14:30:33","modified_gmt":"2026-04-15T19:30:33","slug":"activated-neutrophils-are-a-hallmark-of-acute-lung-injury","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/activated-neutrophils-are-a-hallmark-of-acute-lung-injury","title":{"rendered":"Activated neutrophils are a hallmark of acute lung injury"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/activated-neutrophils-are-a-hallmark-of-acute-lung-injury.jpg\"><\/a><\/p>\n<p>Here, Dolly Mehta &amp; team find loss of ERG in endothelial cells alters neutrophil transcriptome towards inflammatory lineage via IL8\/CXCR2 and CXCR2 blockade with Reparixin reduces inflammation, neutrophil infiltration, and improves survival in a pneumonia model.<\/p>\n<p>The figure shows mouse lungs 30 minutes after antibody administration, with increased number of neutrophils (green) in Erg-null mice compared with Ergfl\/fl mice. Endothelium (red).<\/p>\n<hr>\n<p>\n<sup>1<\/sup>Department of Pharmacology and Regenerative Medicine, and.<\/p>\n<p><sup>2<\/sup>Division of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois Chicago, College of Medicine, Chicago, Illinois, USA.<\/p>\n<p>Address correspondence to: Dolly Mehta, Department of Pharmacology and Regenerative Medicine, University of Illinois, Chicago, College of Medicine, 835 S. Wolcott Avenue, Chicago, Illinois 60,612, USA. Phone: 312.355.0236; Email: <a href=\"mailto:dmehta@uic.edu\">dmehta@uic.edu<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Here, Dolly Mehta &amp; team find loss of ERG in endothelial cells alters neutrophil transcriptome towards inflammatory lineage via IL8\/CXCR2 and CXCR2 blockade with Reparixin reduces inflammation, neutrophil infiltration, and improves survival in a pneumonia model. The figure shows mouse lungs 30 minutes after antibody administration, with increased number of neutrophils (green) in Erg-null mice [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1512],"tags":[],"class_list":["post-235267","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-mobile-phones"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235267","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=235267"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235267\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=235267"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=235267"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=235267"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}