{"id":235218,"date":"2026-04-14T22:50:46","date_gmt":"2026-04-15T03:50:46","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/abstract-in-obesity-the-heart-muscle-can-thicken-preventing-it-from-relaxing-properly-between-beats"},"modified":"2026-04-14T22:50:46","modified_gmt":"2026-04-15T03:50:46","slug":"abstract-in-obesity-the-heart-muscle-can-thicken-preventing-it-from-relaxing-properly-between-beats","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/abstract-in-obesity-the-heart-muscle-can-thicken-preventing-it-from-relaxing-properly-between-beats","title":{"rendered":"Abstract: In obesity, the heart muscle can thicken, preventing it from relaxing properly between beats"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/abstract126.jpg\"><\/a><\/p>\n<p>While diet and inflammation likely contribute, the underlying molecular mechanism has been unclear.<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1172\/JCI196238\">https:\/\/doi.org\/10.1172\/JCI196238<\/a> Here, Junichi Sadoshima &amp; team find direct stimulation of IL-6 transcription by PPAR\u03b1 in cardiomyocytes plays an important role in mediating the initial development of obesity cardiomyopathy.<\/p>\n<p>The figure indicates binding of PPAR\u03b1 to NFkB (via PLA assay).<\/p>\n<hr>\n<p>\n<sup>1<\/sup>Rutgers New Jersey Medical School Department of Cell Biology and Molecular Medicine, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA.<\/p>\n<p><sup>2<\/sup>Precision Medicine Research Center, College of Medicine, The Catholic University of Korea, Seoul, Korea.<\/p>\n<p>Address correspondence to: Junichi Sadoshima, Cardiovascular Research Institute, Rutgers Biomedical and Health Science, 185 South Orange Ave., MSB G609, Newark, New Jersey, 7,103, USA. Phone 973.972.8619; Email: <a href=\"mailto:sadoshju@njms.rutgers.edu\">sadoshju@njms.rutgers.edu<\/a>.<\/p>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2026\/04\/abstract-in-obesity-the-heart-muscle-can-thicken-preventing-it-from-relaxing-properly-between-beats\">Continue reading \u201cAbstract: In obesity, the heart muscle can thicken, preventing it from relaxing properly between beats\u201d | &gt;<\/a><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"<p>While diet and inflammation likely contribute, the underlying molecular mechanism has been unclear. https:\/\/doi.org\/10.1172\/JCI196238 Here, Junichi Sadoshima &amp; team find direct stimulation of IL-6 transcription by PPAR\u03b1 in cardiomyocytes plays an important role in mediating the initial development of obesity cardiomyopathy. The figure indicates binding of PPAR\u03b1 to NFkB (via PLA assay). 1Rutgers New Jersey [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1495,1512],"tags":[],"class_list":["post-235218","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-health","category-mobile-phones"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235218","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=235218"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235218\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=235218"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=235218"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=235218"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}