{"id":235215,"date":"2026-04-14T22:35:30","date_gmt":"2026-04-15T03:35:30","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/a-missing-link-in-how-the-brain-regulates-appetite"},"modified":"2026-04-14T22:35:30","modified_gmt":"2026-04-15T03:35:30","slug":"a-missing-link-in-how-the-brain-regulates-appetite","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/a-missing-link-in-how-the-brain-regulates-appetite","title":{"rendered":"A missing link in how the brain regulates appetite"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/a-missing-link-in-how-the-brain-regulates-appetite2.jpg\"><\/a><\/p>\n<p>Bile acids at the center of hepato-ocular crosstalk.<\/p>\n<p>Hepatic dysfunction with ocular pathology has been linked to dysregulated bile acid metabolism.<\/p>\n<p>Bile acid imbalance has been shown to drive ocular injury along the gut-liver-eye axis through direct cytotoxicity, disruption of retinal and lens homeostasis mediated by FXR and TGR5 signaling, and immune activation and these mechanisms are implicated across a spectrum of conditions, ranging from inborn metabolic disorders to acquired cholestatic diseases.<\/p>\n<p>The researchers in this review discuss translational potential of targeting bile acid homeostasis and summarize emerging therapeutic strategies, including bile acid-based interventions, targeted drug delivery, and microbiome modulation, that aim to restore systemic bile acid balance.<\/p>\n<p>Thus, bile acid homeostasis act as a unifying therapeutic framework for hepato-ocular comorbidities. sciencenewshighlights ScienceMission <a href=\"https:\/\/sciencemission.com\/Hepato-ocular-crosstalk\">https:\/\/sciencemission.com\/Hepato-ocular-crosstalk<\/a><\/p>\n<hr>\n<p>Health sciences.<\/p>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2026\/04\/a-missing-link-in-how-the-brain-regulates-appetite\">Continue reading \u201cA missing link in how the brain regulates appetite\u201d | &gt;<\/a><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bile acids at the center of hepato-ocular crosstalk. Hepatic dysfunction with ocular pathology has been linked to dysregulated bile acid metabolism. Bile acid imbalance has been shown to drive ocular injury along the gut-liver-eye axis through direct cytotoxicity, disruption of retinal and lens homeostasis mediated by FXR and TGR5 signaling, and immune activation and these [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1495,47],"tags":[],"class_list":["post-235215","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-health","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235215","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=235215"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235215\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=235215"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=235215"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=235215"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}