{"id":235175,"date":"2026-04-14T18:11:45","date_gmt":"2026-04-14T23:11:45","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/scap-stabilizes-pkm2-to-promote-glycolysis-and-enhance-anti-fungal-immunity-in-macrophages"},"modified":"2026-04-14T18:11:45","modified_gmt":"2026-04-14T23:11:45","slug":"scap-stabilizes-pkm2-to-promote-glycolysis-and-enhance-anti-fungal-immunity-in-macrophages","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/scap-stabilizes-pkm2-to-promote-glycolysis-and-enhance-anti-fungal-immunity-in-macrophages","title":{"rendered":"Scap stabilizes PKM2 to promote glycolysis and enhance anti-fungal immunity in macrophages"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/scap-stabilizes-pkm2-to-promote-glycolysis-and-enhance-anti-fungal-immunity-in-macrophages2.jpg\"><\/a><\/p>\n<p>Huang et al. identify Scap as a key regulator of macrophage anti-fungal immunity that stabilizes PKM2 and sustains glycolysis independently of SREBP-mediated lipid synthesis, thereby establishing a Scap-PKM2 axis essential for cytokine production, phagocytosis, and fungal control.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Huang et al. identify Scap as a key regulator of macrophage anti-fungal immunity that stabilizes PKM2 and sustains glycolysis independently of SREBP-mediated lipid synthesis, thereby establishing a Scap-PKM2 axis essential for cytokine production, phagocytosis, and fungal control.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-235175","post","type-post","status-publish","format-standard","hentry","category-futurism"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235175","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=235175"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235175\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=235175"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=235175"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=235175"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}