{"id":235085,"date":"2026-04-13T18:21:26","date_gmt":"2026-04-13T23:21:26","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/single-nucleus-multiome-analysis-in-the-human-prefrontal-cortex-identifies-gene-expression-and-cis-regulatory-elements-associated-with-aging"},"modified":"2026-04-13T18:21:26","modified_gmt":"2026-04-13T23:21:26","slug":"single-nucleus-multiome-analysis-in-the-human-prefrontal-cortex-identifies-gene-expression-and-cis-regulatory-elements-associated-with-aging","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/single-nucleus-multiome-analysis-in-the-human-prefrontal-cortex-identifies-gene-expression-and-cis-regulatory-elements-associated-with-aging","title":{"rendered":"Single-nucleus multiome analysis in the human prefrontal cortex identifies gene expression and cis-regulatory elements associated with aging"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/single-nucleus-multiome-analysis-in-the-human-prefrontal-cortex-identifies-gene-expression-and-cis-regulatory-elements-associated-with-aging2.jpg\"><\/a><\/p>\n<p>Catching et al. use single-nucleus ATAC plus gene expression to profile 357 neurologically unaffected postmortem human prefrontal cortices and characterize the molecular effects of aging on different cell types. Analysis of each cell type identifies genes and chromatin regions associated with aging in the human prefrontal cortex.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Catching et al. use single-nucleus ATAC plus gene expression to profile 357 neurologically unaffected postmortem human prefrontal cortices and characterize the molecular effects of aging on different cell types. Analysis of each cell type identifies genes and chromatin regions associated with aging in the human prefrontal cortex.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[269],"tags":[],"class_list":["post-235085","post","type-post","status-publish","format-standard","hentry","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235085","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=235085"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235085\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=235085"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=235085"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=235085"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}