{"id":235066,"date":"2026-04-12T22:05:59","date_gmt":"2026-04-13T03:05:59","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/affecting-a-signaling-pathway-alleviates-alzheimers-in-mice"},"modified":"2026-04-12T22:05:59","modified_gmt":"2026-04-13T03:05:59","slug":"affecting-a-signaling-pathway-alleviates-alzheimers-in-mice","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/affecting-a-signaling-pathway-alleviates-alzheimers-in-mice","title":{"rendered":"Affecting a Signaling Pathway Alleviates Alzheimer\u2019s in Mice"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/affecting-a-signaling-pathway-alleviates-alzheimers-in-mice.jpg\"><\/a><\/p>\n<p>A new study shows that the overexpression of somatostatin (SST), a neuropeptide produced in neurons and acting mostly on microglia, <a href=\"https:\/\/doi.org\/10.1016\/j.bbi.2026.106563\">lowers inflammation and amyloid \u03b2 burden, improving cognitive abilities in a mouse model of Alzheimer\u2019s<\/a>. Drugs affecting this pathway are already available [1].<\/p>\n<p><b><b>The unusual suspect<\/b><\/b><\/p>\n<p>In Alzheimer\u2019s disease, many signaling pathways in the brain become dysregulated. Since going after the main hallmarks of the disease (amyloid \u03b2 and tau protein accumulation) has only yielded modest results so far, scientists are exploring various secondary targets whose levels correlate with the disease.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new study shows that the overexpression of somatostatin (SST), a neuropeptide produced in neurons and acting mostly on microglia, lowers inflammation and amyloid \u03b2 burden, improving cognitive abilities in a mouse model of Alzheimer\u2019s. Drugs affecting this pathway are already available [1]. The unusual suspect In Alzheimer\u2019s disease, many signaling pathways in the brain [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-235066","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235066","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=235066"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235066\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=235066"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=235066"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=235066"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}