{"id":235061,"date":"2026-04-12T18:18:07","date_gmt":"2026-04-12T23:18:07","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/single-cell-epigenomics-uncovers-heterochromatin-instability-and-transcription-factor-dysfunction-during-mouse-brain-aging"},"modified":"2026-04-12T18:18:07","modified_gmt":"2026-04-12T23:18:07","slug":"single-cell-epigenomics-uncovers-heterochromatin-instability-and-transcription-factor-dysfunction-during-mouse-brain-aging","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/single-cell-epigenomics-uncovers-heterochromatin-instability-and-transcription-factor-dysfunction-during-mouse-brain-aging","title":{"rendered":"Single-cell epigenomics uncovers heterochromatin instability and transcription factor dysfunction during mouse brain aging"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/single-cell-epigenomics-uncovers-heterochromatin-instability-and-transcription-factor-dysfunction-during-mouse-brain-aging2.jpg\"><\/a><\/p>\n<p>Amaral et al. present a single-cell atlas of brain aging, revealing coordinated chromatin and gene expression changes across multiple regions from young to old mice. Their analyses show that aging involves loss of progenitor cells, dysregulation of master transcription factors, and destabilization of heterochromatin, driving a gradual erosion of cellular identity.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Amaral et al. present a single-cell atlas of brain aging, revealing coordinated chromatin and gene expression changes across multiple regions from young to old mice. Their analyses show that aging involves loss of progenitor cells, dysregulation of master transcription factors, and destabilization of heterochromatin, driving a gradual erosion of cellular identity.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[269,47],"tags":[],"class_list":["post-235061","post","type-post","status-publish","format-standard","hentry","category-life-extension","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235061","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=235061"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235061\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=235061"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=235061"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=235061"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}