{"id":235057,"date":"2026-04-12T18:13:36","date_gmt":"2026-04-12T23:13:36","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/targeting-the-dstyk-ulk1-axis-rewires-tnfr1-signaling-to-overcome-treatment-resistance-in-lung-cancer"},"modified":"2026-04-12T18:13:36","modified_gmt":"2026-04-12T23:13:36","slug":"targeting-the-dstyk-ulk1-axis-rewires-tnfr1-signaling-to-overcome-treatment-resistance-in-lung-cancer","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/targeting-the-dstyk-ulk1-axis-rewires-tnfr1-signaling-to-overcome-treatment-resistance-in-lung-cancer","title":{"rendered":"Targeting the DSTYK-ULK1 axis rewires TNFR1 signaling to overcome treatment resistance in lung cancer"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/targeting-the-dstyk-ulk1-axis-rewires-tnfr1-signaling-to-overcome-treatment-resistance-in-lung-cancer2.jpg\"><\/a><\/p>\n<p>DSTYK amplification enables lung cancer cells to evade T cell killing by sustaining ULK1-dependent suppression of TNF-\u03b1-induced apoptosis. Targeting ULK1 dismantles this <i>survival<\/i> pathway, restoring RIPK1-mediated cell death and sensitizing DSTYK-altered tumors to chemo-immunotherapy, revealing a promising therapeutic vulnerability in NSCLC.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>DSTYK amplification enables lung cancer cells to evade T cell killing by sustaining ULK1-dependent suppression of TNF-\u03b1-induced apoptosis. Targeting ULK1 dismantles this survival pathway, restoring RIPK1-mediated cell death and sensitizing DSTYK-altered tumors to chemo-immunotherapy, revealing a promising therapeutic vulnerability in NSCLC.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-235057","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235057","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=235057"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/235057\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=235057"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=235057"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=235057"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}