{"id":234933,"date":"2026-04-10T07:30:45","date_gmt":"2026-04-10T12:30:45","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/long-non-coding-rna-may-be-a-promising-therapeutic-target-for-cancer"},"modified":"2026-04-10T07:30:45","modified_gmt":"2026-04-10T12:30:45","slug":"long-non-coding-rna-may-be-a-promising-therapeutic-target-for-cancer","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/long-non-coding-rna-may-be-a-promising-therapeutic-target-for-cancer","title":{"rendered":"Long non-coding RNA may be a promising therapeutic target for cancer"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/long-non-coding-rna-may-be-a-promising-therapeutic-target-for-cancer.jpg\"><\/a><\/p>\n<p>Northwestern Medicine scientists have discovered that a specific long non-coding RNA activates oncogenic signaling pathways in prostate cancer cells and drives tumor progression, underscoring its potential as a therapeutic target, according to a recent study <a href=\"https:\/\/www.nature.com\/articles\/s41467-026-70814-4\" target=\"_blank\">published<\/a> in <i>Nature Communications.<\/i> Rendong Yang, Ph.D., associate professor of Urology and a member of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, was co-corresponding author of the study.<\/p>\n<p>Long non-coding RNAs (lncRNAs) are a type of RNA with transcripts that contain more than 200 nucleotides and play a central role in regulating gene expression, most notably in cancer progression. While previous work has identified many cancer-associated lncRNAs, the mechanisms by which lncRNAs influence cancer progression have remained unknown due to lncRNAs\u2019 cell type-specific and tissue-specific gene expression patterns.<\/p>\n<p>In the current study, the scientists aimed to uncover cellular interactions between super-enhancers\u2014clusters of regulatory DNA elements that drive high levels of transcription\u2014and lncRNAs by studying RNA sequencing data from patients with metastatic castration-resistant prostate cancer.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Northwestern Medicine scientists have discovered that a specific long non-coding RNA activates oncogenic signaling pathways in prostate cancer cells and drives tumor progression, underscoring its potential as a therapeutic target, according to a recent study published in Nature Communications. Rendong Yang, Ph.D., associate professor of Urology and a member of the Robert H. Lurie Comprehensive [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-234933","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234933","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=234933"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234933\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=234933"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=234933"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=234933"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}