{"id":234914,"date":"2026-04-10T03:55:26","date_gmt":"2026-04-10T08:55:26","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/lamin-a-c-safeguards-replication-initiation-by-orchestrating-chromatin-accessibility-and-pcna-recruitment"},"modified":"2026-04-10T03:55:26","modified_gmt":"2026-04-10T08:55:26","slug":"lamin-a-c-safeguards-replication-initiation-by-orchestrating-chromatin-accessibility-and-pcna-recruitment","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/lamin-a-c-safeguards-replication-initiation-by-orchestrating-chromatin-accessibility-and-pcna-recruitment","title":{"rendered":"Lamin A\/C safeguards replication initiation by orchestrating chromatin accessibility and PCNA recruitment"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/lamin-a-c-safeguards-replication-initiation-by-orchestrating-chromatin-accessibility-and-pcna-recruitment2.jpg\"><\/a><\/p>\n<p>Zhang et al. reveal lamin A\/C as a gatekeeper of replication initiation through effects on chromatin organization and PCNA availability in early S phase. Lamin A\/C deficiency disrupts these controls, increasing initiation density and replication-dependent DNA damage.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Zhang et al. reveal lamin A\/C as a gatekeeper of replication initiation through effects on chromatin organization and PCNA availability in early S phase. Lamin A\/C deficiency disrupts these controls, increasing initiation density and replication-dependent DNA damage.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-234914","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234914","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=234914"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234914\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=234914"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=234914"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=234914"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}