{"id":234879,"date":"2026-04-09T23:06:13","date_gmt":"2026-04-10T04:06:13","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/your-dna-has-a-secret-second-code-that-decides-which-genes-get-silenced"},"modified":"2026-04-09T23:06:13","modified_gmt":"2026-04-10T04:06:13","slug":"your-dna-has-a-secret-second-code-that-decides-which-genes-get-silenced","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/your-dna-has-a-secret-second-code-that-decides-which-genes-get-silenced","title":{"rendered":"Your DNA has a secret \u201csecond code\u201d that decides which genes get silenced"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/your-dna-has-a-secret-second-code-that-decides-which-genes-get-silenced.webp\"><\/a><\/p>\n<p>However, research is increasingly showing that these so-called synonymous codons are not truly equal. Some codons make mRNA molecules more stable and easier for cells to translate into proteins, making them more efficient. Others, considered non-optimal, lead to weaker translation and are more likely to be broken down. Until now, scientists have not fully understood how human cells recognize and respond to these less efficient codons.<\/p>\n<p><strong>Scientists <i>Search<\/i> for the Cell\u2019s \u201cQuality Control\u201d System<\/strong><\/p>\n<p>To investigate this question, a research team from Kyoto University and RIKEN, led by Osamu Takeuchi and Takuhiro Ito, carried out a series of experiments aimed at uncovering how cells handle codon efficiency.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>However, research is increasingly showing that these so-called synonymous codons are not truly equal. Some codons make mRNA molecules more stable and easier for cells to translate into proteins, making them more efficient. Others, considered non-optimal, lead to weaker translation and are more likely to be broken down. Until now, scientists have not fully understood [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-234879","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234879","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=234879"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234879\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=234879"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=234879"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=234879"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}