{"id":234831,"date":"2026-04-08T23:22:41","date_gmt":"2026-04-09T04:22:41","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/dna-polymerase-%ce%bc-protects-macrophages-from-dna-damage-produced-during-pro-inflammatory-activation"},"modified":"2026-04-08T23:22:41","modified_gmt":"2026-04-09T04:22:41","slug":"dna-polymerase-%ce%bc-protects-macrophages-from-dna-damage-produced-during-pro-inflammatory-activation","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/dna-polymerase-%ce%bc-protects-macrophages-from-dna-damage-produced-during-pro-inflammatory-activation","title":{"rendered":"DNA polymerase \u03bc protects macrophages from DNA damage produced during pro-inflammatory activation"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/dna-polymerase-cebc-protects-macrophages-from-dna-damage-produced-during-pro-inflammatory-activation2.jpg\"><\/a><\/p>\n<p>Pol\u03bc is induced in macrophages by ROS upon pro-inflammatory stimuli and is essential for efficient repair of DNA double-strand breaks. Its deficiency compromises macrophage survival and persistence in inflammatory models of infection and tissue repair, underscoring Pol\u03bc\u2019s critical role in counteracting ROS-mediated genotoxic stress and in achieving a correct inflammatory resolution.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pol\u03bc is induced in macrophages by ROS upon pro-inflammatory stimuli and is essential for efficient repair of DNA double-strand breaks. Its deficiency compromises macrophage survival and persistence in inflammatory models of infection and tissue repair, underscoring Pol\u03bc\u2019s critical role in counteracting ROS-mediated genotoxic stress and in achieving a correct inflammatory resolution.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-234831","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234831","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=234831"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234831\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=234831"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=234831"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=234831"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}