{"id":234753,"date":"2026-04-07T11:09:57","date_gmt":"2026-04-07T16:09:57","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/cell-confinement-initiates-a-delayed-but-heritable-loss-of-chromosomes"},"modified":"2026-04-07T11:09:57","modified_gmt":"2026-04-07T16:09:57","slug":"cell-confinement-initiates-a-delayed-but-heritable-loss-of-chromosomes","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/cell-confinement-initiates-a-delayed-but-heritable-loss-of-chromosomes","title":{"rendered":"Cell confinement initiates a delayed but heritable loss of chromosomes"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/cell-confinement-initiates-a-delayed-but-heritable-loss-of-chromosomes2.jpg\"><\/a><\/p>\n<p>Solid tumors show frequent chromosome loss and some compressed cells. Phan et al. show mitotic spindle perturbations cause mis-segregation of chromosomes and <i>heritable<\/i> chromosome loss. The effects are facets of a \u201cmemory\u201d that phenocopies standard nocodazole washout experiments, including cell death and arrest, and that proves insensitive to compression beyond a threshold.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Solid tumors show frequent chromosome loss and some compressed cells. Phan et al. show mitotic spindle perturbations cause mis-segregation of chromosomes and heritable chromosome loss. The effects are facets of a \u201cmemory\u201d that phenocopies standard nocodazole washout experiments, including cell death and arrest, and that proves insensitive to compression beyond a threshold.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-234753","post","type-post","status-publish","format-standard","hentry","category-futurism"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234753","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=234753"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234753\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=234753"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=234753"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=234753"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}