{"id":234746,"date":"2026-04-07T02:48:51","date_gmt":"2026-04-07T07:48:51","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/apolipoprotein-e-mimetic-peptide-cn-105-and-postoperative-delirium-in-older-patients-the-phase-2-marble-randomized-clinical-trial"},"modified":"2026-04-07T02:48:51","modified_gmt":"2026-04-07T07:48:51","slug":"apolipoprotein-e-mimetic-peptide-cn-105-and-postoperative-delirium-in-older-patients-the-phase-2-marble-randomized-clinical-trial","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/apolipoprotein-e-mimetic-peptide-cn-105-and-postoperative-delirium-in-older-patients-the-phase-2-marble-randomized-clinical-trial","title":{"rendered":"Apolipoprotein E Mimetic Peptide CN-105 and Postoperative Delirium in Older Patients: The Phase 2 MARBLE Randomized Clinical Trial"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/apolipoprotein-e-mimetic-peptide-cn-105-and-postoperative-delirium-in-older-patients-the-phase-2-marble-randomized-clinical-trial.jpg\"><\/a><\/p>\n<p>A phase 2 trial found that the apoE mimetic peptide CN-105 was safe and feasible in older adults after surgery, supporting the need for a phase 3 trial to assess effects on postoperative delirium.<\/p>\n<hr>\n<p>This randomized clinical trial investigates the safety and feasibility of the apolipoprotein E mimetic peptide CN-105 vs placebo for reducing postoperative delirium in older patients.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A phase 2 trial found that the apoE mimetic peptide CN-105 was safe and feasible in older adults after surgery, supporting the need for a phase 3 trial to assess effects on postoperative delirium. This randomized clinical trial investigates the safety and feasibility of the apolipoprotein E mimetic peptide CN-105 vs placebo for reducing postoperative [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-234746","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234746","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=234746"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234746\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=234746"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=234746"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=234746"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}