{"id":234660,"date":"2026-04-06T03:13:53","date_gmt":"2026-04-06T08:13:53","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/targeting-metabolism-to-combat-anticancer-and-antibacterial-drug-resistance"},"modified":"2026-04-06T03:13:53","modified_gmt":"2026-04-06T08:13:53","slug":"targeting-metabolism-to-combat-anticancer-and-antibacterial-drug-resistance","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/targeting-metabolism-to-combat-anticancer-and-antibacterial-drug-resistance","title":{"rendered":"Targeting metabolism to combat anticancer and antibacterial drug resistance"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/targeting-metabolism-to-combat-anticancer-and-antibacterial-drug-resistance.jpg\"><\/a><\/p>\n<p>Combating anticancer and antibacterial drug resistance by metabolic targeting.<\/p>\n<p>Bacteria and cancer cells activate defense mechanisms driven by central carbon and amino acid metabolism to overcome drug-induced stress.<\/p>\n<p>Drug tolerance and persistence are driven by a dormant state in bacteria, whereas cancer cells upregulate energy metabolism to withstand prolonged drug exposure.<\/p>\n<p>Biofilms, granulomas, and the tumor microenvironment share hypoxic and acidic conditions, where cells rely on anaerobic and lipid metabolism for survival.<\/p>\n<p>Macrophage immunometabolism influences disease progression in tuberculosis and cancer. Common approaches for overcoming drug resistance include blocking metabolic targets that enhance drug lethality and synergistic drug combinations.<\/p>\n<p>Drug repurposing, dietary interventions, and immunotherapy have shown use in cancer, but their antibacterial potential remains underexplored. sciencenewshighlights ScienceMission <a href=\"https:\/\/sciencemission.com\/Targeting-metabolism-to-combat-anticancer\">https:\/\/sciencemission.com\/Targeting-metabolism-to-combat-anticancer<\/a><\/p>\n<hr>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2026\/04\/targeting-metabolism-to-combat-anticancer-and-antibacterial-drug-resistance\">Continue reading \u201cTargeting metabolism to combat anticancer and antibacterial drug resistance\u201d | &gt;<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Combating anticancer and antibacterial drug resistance by metabolic targeting. Bacteria and cancer cells activate defense mechanisms driven by central carbon and amino acid metabolism to overcome drug-induced stress. Drug tolerance and persistence are driven by a dormant state in bacteria, whereas cancer cells upregulate energy metabolism to withstand prolonged drug exposure. Biofilms, granulomas, and the [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,6],"tags":[],"class_list":["post-234660","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-robotics-ai"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234660","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=234660"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234660\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=234660"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=234660"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=234660"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}