{"id":234654,"date":"2026-04-05T22:07:40","date_gmt":"2026-04-06T03:07:40","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/pyruvate-kinase-activators-in-hereditary-haemolytic-anaemias-current-evidence-and-clinical-potential"},"modified":"2026-04-05T22:07:40","modified_gmt":"2026-04-06T03:07:40","slug":"pyruvate-kinase-activators-in-hereditary-haemolytic-anaemias-current-evidence-and-clinical-potential","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/pyruvate-kinase-activators-in-hereditary-haemolytic-anaemias-current-evidence-and-clinical-potential","title":{"rendered":"Pyruvate kinase activators in hereditary haemolytic anaemias: current evidence and clinical potential"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/pyruvate-kinase-activators-in-hereditary-haemolytic-anaemias-current-evidence-and-clinical-potential2.jpg\"><\/a><\/p>\n<p>Glycogen and lactate metabolism in mouse fetal Sertoli cells sustain the germ line.<\/p>\n<hr>\n<p>Estermann and Sheheen et al. identified a metabolic coupling between fetal Sertoli and germ cells in mice, driven by glycogen breakdown and lactate transport through the MCT4\/MCT1 shuttle. This interaction is essential to support fetal germ cell development.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Glycogen and lactate metabolism in mouse fetal Sertoli cells sustain the germ line. Estermann and Sheheen et al. identified a metabolic coupling between fetal Sertoli and germ cells in mice, driven by glycogen breakdown and lactate transport through the MCT4\/MCT1 shuttle. This interaction is essential to support fetal germ cell development.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-234654","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234654","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=234654"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234654\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=234654"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=234654"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=234654"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}