{"id":234630,"date":"2026-04-04T22:07:04","date_gmt":"2026-04-05T03:07:04","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/adar1-regulates-dsrna-formation-in-nuclear-and-mitochondrial-transcripts-through-editing-dependent-and-independent-mechanisms"},"modified":"2026-04-04T22:07:04","modified_gmt":"2026-04-05T03:07:04","slug":"adar1-regulates-dsrna-formation-in-nuclear-and-mitochondrial-transcripts-through-editing-dependent-and-independent-mechanisms","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/adar1-regulates-dsrna-formation-in-nuclear-and-mitochondrial-transcripts-through-editing-dependent-and-independent-mechanisms","title":{"rendered":"ADAR1 regulates dsRNA formation in nuclear and mitochondrial transcripts through editing-dependent and \u2014independent mechanisms"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/adar1-regulates-dsrna-formation-in-nuclear-and-mitochondrial-transcripts-through-editing-dependent-and-independent-mechanisms.jpg\"><\/a><\/p>\n<p>We report that the RNA-editing enzyme ADAR1 downregulates nuclear-and mitochondria-encoded double-stranded RNAs (dsRNAs) to maintain immune homeostasis. ADAR1 employs RNA-editing-dependent and-independent mechanisms to keep dsRNA levels low in cells. Notably, upon ADAR1 loss, mitochondrial dsRNA levels increase and can cause enhanced inflammation upon mitochondrial stress.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>We report that the RNA-editing enzyme ADAR1 downregulates nuclear-and mitochondria-encoded double-stranded RNAs (dsRNAs) to maintain immune homeostasis. ADAR1 employs RNA-editing-dependent and-independent mechanisms to keep dsRNA levels low in cells. Notably, upon ADAR1 loss, mitochondrial dsRNA levels increase and can cause enhanced inflammation upon mitochondrial stress.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-234630","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234630","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=234630"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234630\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=234630"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=234630"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=234630"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}