{"id":234484,"date":"2026-04-02T11:12:40","date_gmt":"2026-04-02T16:12:40","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/functionally-distinct-alk-and-ros1-fusions-detected-in-infant-type-hemispheric-gliomas-converge-on-stat3-and-shp2-activation"},"modified":"2026-04-02T11:12:40","modified_gmt":"2026-04-02T16:12:40","slug":"functionally-distinct-alk-and-ros1-fusions-detected-in-infant-type-hemispheric-gliomas-converge-on-stat3-and-shp2-activation","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/functionally-distinct-alk-and-ros1-fusions-detected-in-infant-type-hemispheric-gliomas-converge-on-stat3-and-shp2-activation","title":{"rendered":"Functionally distinct ALK and ROS1 fusions detected in infant-type hemispheric gliomas converge on STAT3 and SHP2 activation"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/functionally-distinct-alk-and-ros1-fusions-detected-in-infant-type-hemispheric-gliomas-converge-on-stat3-and-shp2-activation2.jpg\"><\/a><\/p>\n<p>Postlmayr et al. show that ALK and ROS1 fusions identified in IHG drive increased STAT3 and SHP2 signaling, revealed by multi-omic integrative analyses and validated <i>in vitro<\/i> and <i>in vivo.<\/i> Distinct microtubule-binding fusion <i>partner<\/i>s further promote a hypermotile, invasion-prone phenotype, highlighting the role of fusion <i>partner<\/i>s in specific tumorigenic behavior.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Postlmayr et al. show that ALK and ROS1 fusions identified in IHG drive increased STAT3 and SHP2 signaling, revealed by multi-omic integrative analyses and validated in vitro and in vivo. Distinct microtubule-binding fusion partners further promote a hypermotile, invasion-prone phenotype, highlighting the role of fusion partners in specific tumorigenic behavior.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-234484","post","type-post","status-publish","format-standard","hentry","category-futurism"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234484","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=234484"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234484\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=234484"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=234484"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=234484"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}