{"id":234428,"date":"2026-04-01T19:14:30","date_gmt":"2026-04-02T00:14:30","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/potentiating-dendritic-cell-immunotherapy-by-interrupting-the-semaphorin-4d-induced-immune-suppressive-barrier"},"modified":"2026-04-01T19:14:30","modified_gmt":"2026-04-02T00:14:30","slug":"potentiating-dendritic-cell-immunotherapy-by-interrupting-the-semaphorin-4d-induced-immune-suppressive-barrier","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/potentiating-dendritic-cell-immunotherapy-by-interrupting-the-semaphorin-4d-induced-immune-suppressive-barrier","title":{"rendered":"Potentiating dendritic cell immunotherapy by interrupting the Semaphorin 4D-induced immune-suppressive barrier"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/potentiating-dendritic-cell-immunotherapy-by-interrupting-the-semaphorin-4d-induced-immune-suppressive-barrier.jpg\"><\/a><\/p>\n<p>Garg et al. report that blocking the molecule <i>SEMA4D<\/i> strengthens immune responses against HER2-positive breast cancer. When paired with specialized dendritic cells, this approach boosts anti-tumor immune activity, reduces suppressive cells, and enables clearance of both local and distant tumors. Their findings support a promising and well-tolerated immunotherapy strategy.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Garg et al. report that blocking the molecule SEMA4D strengthens immune responses against HER2-positive breast cancer. When paired with specialized dendritic cells, this approach boosts anti-tumor immune activity, reduces suppressive cells, and enables clearance of both local and distant tumors. Their findings support a promising and well-tolerated immunotherapy strategy.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-234428","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234428","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=234428"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234428\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=234428"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=234428"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=234428"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}