{"id":234399,"date":"2026-04-01T02:12:09","date_gmt":"2026-04-01T07:12:09","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/study-reveals-why-some-cancer-therapies-dont-work-for-all-patients"},"modified":"2026-04-01T02:12:09","modified_gmt":"2026-04-01T07:12:09","slug":"study-reveals-why-some-cancer-therapies-dont-work-for-all-patients","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/study-reveals-why-some-cancer-therapies-dont-work-for-all-patients","title":{"rendered":"Study reveals why some cancer therapies don\u2019t work for all patients"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/study-reveals-why-some-cancer-therapies-dont-work-for-all-patients2.jpg\"><\/a><\/p>\n<p>Drugs that block enzymes called tyrosine kinases are among the most effective targeted therapies for cancer. However, they typically work for only 40 to 80 percent of the patients who would be expected to respond to them.<\/p>\n<p>In a new study, MIT researchers have figured out why those drugs don\u2019t work in all cases: Many of these tumors have turned on a backup survival pathway that helps them keep growing when the targeted pathway is knocked out.<\/p>\n<p>\u201cThis seems to be hardwired into the cells and seems to be providing activation of a critical survival pathway in cancer cells,\u201d says Forest White, the Ned C. and Janet C. Rice Professor of Biological Engineering at MIT. \u201cThis pathway allows the cells to be resistant to a wide variety of therapies, including chemotherapies.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Drugs that block enzymes called tyrosine kinases are among the most effective targeted therapies for cancer. However, they typically work for only 40 to 80 percent of the patients who would be expected to respond to them. In a new study, MIT researchers have figured out why those drugs don\u2019t work in all cases: Many [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-234399","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234399","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=234399"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234399\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=234399"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=234399"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=234399"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}