{"id":234396,"date":"2026-04-01T02:11:18","date_gmt":"2026-04-01T07:11:18","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/04\/significant-genes-associated-with-mortality-and-disease-progression-in-grade-ii-and-iii-glioma"},"modified":"2026-04-01T02:11:18","modified_gmt":"2026-04-01T07:11:18","slug":"significant-genes-associated-with-mortality-and-disease-progression-in-grade-ii-and-iii-glioma","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/04\/significant-genes-associated-with-mortality-and-disease-progression-in-grade-ii-and-iii-glioma","title":{"rendered":"Significant Genes Associated with Mortality and Disease Progression in Grade II and III Glioma"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/significant-genes-associated-with-mortality-and-disease-progression-in-grade-ii-and-iii-glioma2.jpg\"><\/a><\/p>\n<p>Background: The Wnt\/\u03b2-catenin pathway plays a critical role in the tumorigenesis and maintenance of glioma stem cells. This study aimed to evaluate significant genes associated with the Wnt\/\u03b2-catenin pathway involved in mortality and disease progression in patients with grade II and III glioma, using the Cancer Genome Atlas (TCGA) database. Methods: We obtained clinicopathological information and mRNA expression data from 515 patients with grade II and III gliomas from the TCGA database. We performed a multivariate Cox regression analysis to identify genes independently associated with glioma prognosis. Results: The analysis of 34 genes involved in Wnt\/\u03b2-catenin signaling demonstrated that four genes (CER1, FRAT1, FSTL1, and RPSA) related to the Wnt\/\u03b2-catenin pathway were significantly associated with mortality and disease progression in patients with grade II and III glioma.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background: The Wnt\/\u03b2-catenin pathway plays a critical role in the tumorigenesis and maintenance of glioma stem cells. This study aimed to evaluate significant genes associated with the Wnt\/\u03b2-catenin pathway involved in mortality and disease progression in patients with grade II and III glioma, using the Cancer Genome Atlas (TCGA) database. Methods: We obtained clinicopathological information [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-234396","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234396","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=234396"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234396\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=234396"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=234396"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=234396"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}