{"id":234287,"date":"2026-03-30T22:12:20","date_gmt":"2026-03-31T03:12:20","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/abstract-the-pim-kinase-family-is-involved-in-tumorigenesis-yet-its-role-in-primary-t-cells-remains-largely-uncharacterized"},"modified":"2026-03-30T22:12:20","modified_gmt":"2026-03-31T03:12:20","slug":"abstract-the-pim-kinase-family-is-involved-in-tumorigenesis-yet-its-role-in-primary-t-cells-remains-largely-uncharacterized","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/abstract-the-pim-kinase-family-is-involved-in-tumorigenesis-yet-its-role-in-primary-t-cells-remains-largely-uncharacterized","title":{"rendered":"Abstract: The PIM kinase family is involved in tumorigenesis, yet its role in primary T cells remains largely uncharacterized"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/abstract118.jpg\"><\/a><\/p>\n<p><a href=\"https:\/\/doi.org\/10.1172\/JCI192928\">https:\/\/doi.org\/10.1172\/JCI192928<\/a> Here, Xue-Zhong Yu &amp; team identify Pim2 as a key negative regulator of CD8 T-cell antitumor immunity and validate it as a potential therapeutic target for enhancing cancer immunotherapy.<\/p>\n<p>Electron microscopy images show visible autophagosomes in activated WT T cells, but not in Pim2-KO cells, supporting a model in which the PIM2 promotes T cell autophagy.<\/p>\n<hr>\n<p>Address correspondence to: Xue-Zhong Yu or Yongxia Wu, Department of Microbiology and Immunology, Medical College of Wisconsin, 8,701 Watertown Plank Road, Milwaukee, Wisconsin, 53,226, USA. Phone: 414.955.8187; Email: <a href=\"mailto:xuyu@mcw.edu\">xuyu@mcw.edu<\/a> (XZY). Phone: 414.955.8148; Email: <a href=\"mailto:wyongxia@mcw.edu\">wyongxia@mcw.edu<\/a> (YW).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>https:\/\/doi.org\/10.1172\/JCI192928 Here, Xue-Zhong Yu &amp; team identify Pim2 as a key negative regulator of CD8 T-cell antitumor immunity and validate it as a potential therapeutic target for enhancing cancer immunotherapy. Electron microscopy images show visible autophagosomes in activated WT T cells, but not in Pim2-KO cells, supporting a model in which the PIM2 promotes T [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1512],"tags":[],"class_list":["post-234287","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-mobile-phones"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234287","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=234287"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234287\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=234287"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=234287"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=234287"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}