{"id":234161,"date":"2026-03-27T07:10:46","date_gmt":"2026-03-27T12:10:46","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/ipsc-induced-multilineage-liver-organoids-small-intestinal-organoids-and-brain-organoids-sustain-pangenotype-hepatitis-e-virus-propagation"},"modified":"2026-03-27T07:10:46","modified_gmt":"2026-03-27T12:10:46","slug":"ipsc-induced-multilineage-liver-organoids-small-intestinal-organoids-and-brain-organoids-sustain-pangenotype-hepatitis-e-virus-propagation","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/ipsc-induced-multilineage-liver-organoids-small-intestinal-organoids-and-brain-organoids-sustain-pangenotype-hepatitis-e-virus-propagation","title":{"rendered":"IPSC-induced multilineage liver organoids, small intestinal organoids and brain organoids sustain pangenotype hepatitis E virus propagation"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/ipsc-induced-multilineage-liver-organoids-small-intestinal-organoids-and-brain-organoids-sustain-pangenotype-hepatitis-e-virus-propagation.jpg\"><\/a><\/p>\n<p>Liu et al. present via <a href=\"https:\/\/bit.ly\/4bV6X0s\">https:\/\/bit.ly\/4bV6X0s<\/a> (Original research, Hepatology section).<\/p>\n<p>A major step forward for translational research, this study shows that human organoid systems can support replication of multiple hepatitis E virus genotypes\u2014offering a powerful new platform for studying infection and testing therapies.<\/p>\n<hr>\n<p>Background Hepatitis E virus (HEV), the leading global cause of acute viral hepatitis, lacks robust <i>in vitro<\/i> models for virology and pathogenesis research.<\/p>\n<p>Objective We evaluated induced pluripotent stem cell (iPSC)-induced human liver, intestinal and brain organoids (hLOs, hIOs and hBOs) as platforms for HEV infection and replication.<\/p>\n<p>Methods Multilineage organoids were infected with clinical HEV genotypes 1, 3 and 4. Viral tropism, host responses and antiviral efficacy were assessed.<\/p>\n<p>Results All organoids supported the complete life cycle of HEV. hLOs exhibited infection in hepatocytes, cholangiocytes, macrophages and stellate cells, accompanied by elevated interleukin-6 levels, impaired hepatic function (reduced secretion of albumin and Factor IX) and increased levels of alanine aminotransferase and aspartate aminotransferase, indicating hepatocellular injury.<\/p>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2026\/03\/ipsc-induced-multilineage-liver-organoids-small-intestinal-organoids-and-brain-organoids-sustain-pangenotype-hepatitis-e-virus-propagation\">Continue reading \u201cIPSC-induced multilineage liver organoids, small intestinal organoids and brain organoids sustain pangenotype hepatitis E virus propagation\u201d | &gt;<\/a><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Liu et al. present via https:\/\/bit.ly\/4bV6X0s (Original research, Hepatology section). A major step forward for translational research, this study shows that human organoid systems can support replication of multiple hepatitis E virus genotypes\u2014offering a powerful new platform for studying infection and testing therapies. Background Hepatitis E virus (HEV), the leading global cause of acute viral [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-234161","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234161","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=234161"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234161\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=234161"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=234161"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=234161"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}