{"id":234126,"date":"2026-03-26T23:12:52","date_gmt":"2026-03-27T04:12:52","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/abstract-adamts7-has-been-repeatedly-associated-with-coronary-artery-disease"},"modified":"2026-03-26T23:12:52","modified_gmt":"2026-03-27T04:12:52","slug":"abstract-adamts7-has-been-repeatedly-associated-with-coronary-artery-disease","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/abstract-adamts7-has-been-repeatedly-associated-with-coronary-artery-disease","title":{"rendered":"Abstract: ADAMTS7 has been repeatedly associated with coronary artery disease"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/abstract117.jpg\"><\/a><\/p>\n<p><i>ADAMTS7<\/i> has been repeatedly associated with coronary artery disease.<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1172\/JCI187451\">https:\/\/doi.org\/10.1172\/JCI187451<\/a> In this Research Article, Robert C. Bauer &amp; team use the largest human atherosclerosis carotid artery scRNA-seq dataset and new mouse models to demonstrate that <i>ADAMTS7<\/i> is expressed across multiple vascular cell types and contributes to atherosclerosis by promoting lipid accumulation in smooth muscle cells.<\/p>\n<p>The image shows smooth muscle cells labeled with ZsGreen and counterstained with DAPI (blue) for nuclei\u2014indicating increased foam cells from a diet-induced mouse model of atherosclerosis with <i>Adamts7<\/i>-overexpressing SMCs were from SMC origin.<\/p>\n<hr>\n<p>\n<sup>1<\/sup>Cardiometabolic Genomics Program, Division of Cardiology, Department of Medicine, Columbia University, New York, New York, USA.<\/p>\n<p><sup>2<\/sup>Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.<\/p>\n<p>Address correspondence to: Robert C. Bauer, Cardiometabolic Genomics Program, Division of Cardiology, Department of Medicine, Columbia University, 630 W. 168th Street, PS10-401, New York, New York 10,032, USA. Phone: 1.212.342.0952; Email: <a href=\"mailto:rcb36@columbia.edu\">rcb36@columbia.edu<\/a>.<\/p>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2026\/03\/abstract-adamts7-has-been-repeatedly-associated-with-coronary-artery-disease\">Continue reading \u201cAbstract: ADAMTS7 has been repeatedly associated with coronary artery disease\u201d | &gt;<\/a><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"<p>ADAMTS7 has been repeatedly associated with coronary artery disease. https:\/\/doi.org\/10.1172\/JCI187451 In this Research Article, Robert C. Bauer &amp; team use the largest human atherosclerosis carotid artery scRNA-seq dataset and new mouse models to demonstrate that ADAMTS7 is expressed across multiple vascular cell types and contributes to atherosclerosis by promoting lipid accumulation in smooth muscle cells. [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1512],"tags":[],"class_list":["post-234126","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-mobile-phones"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234126","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=234126"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234126\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=234126"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=234126"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=234126"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}