{"id":234125,"date":"2026-03-26T23:09:15","date_gmt":"2026-03-27T04:09:15","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/small-rnas-offer-new-clues-to-schizophrenia-and-bipolar-disorder"},"modified":"2026-03-26T23:09:15","modified_gmt":"2026-03-27T04:09:15","slug":"small-rnas-offer-new-clues-to-schizophrenia-and-bipolar-disorder","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/small-rnas-offer-new-clues-to-schizophrenia-and-bipolar-disorder","title":{"rendered":"Small RNAs offer new clues to schizophrenia and bipolar disorder"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/small-rnas-offer-new-clues-to-schizophrenia-and-bipolar-disorder2.jpg\"><\/a><\/p>\n<p>For decades, scientists studying brain disorders have focused almost exclusively on proteins and the genes encoding them. Now, research from Thomas Jefferson University\u2019s Computational Medicine Center suggests that several classes of small regulatory molecules, fittingly known as small RNAs, may play a much larger role in schizophrenia and bipolar disorder, and in a healthy brain, than previously thought.<\/p>\n<p>In a study recently <a href=\"https:\/\/www.nature.com\/articles\/s41398-026-03808-x\" target=\"_blank\">published<\/a> in <i>Translational Psychiatry<\/i>, a team led by Isidore Rigoutsos, Ph.D. took a comprehensive look at small RNAs in brain samples from people with schizophrenia, bipolar disorder and individuals without psychiatric illness. Their goal was to find out what kind of small RNAs are active in the brain, and whether their levels change in disease.<\/p>\n<p>\u201cLittle attention had been paid to small RNAs in these disorders,\u201d says Dr. Rigoutsos, \u201ceven though small RNAs help control numerous processes by modulating the abundance of genes.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>For decades, scientists studying brain disorders have focused almost exclusively on proteins and the genes encoding them. Now, research from Thomas Jefferson University\u2019s Computational Medicine Center suggests that several classes of small regulatory molecules, fittingly known as small RNAs, may play a much larger role in schizophrenia and bipolar disorder, and in a healthy brain, [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1523,47],"tags":[],"class_list":["post-234125","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-computing","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234125","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=234125"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234125\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=234125"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=234125"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=234125"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}