{"id":234063,"date":"2026-03-25T23:05:59","date_gmt":"2026-03-26T04:05:59","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/local-gene-editing-of-fibroblasts-in-tumors-reveals-a-new-cancer-associated-fibroblast-state"},"modified":"2026-03-25T23:05:59","modified_gmt":"2026-03-26T04:05:59","slug":"local-gene-editing-of-fibroblasts-in-tumors-reveals-a-new-cancer-associated-fibroblast-state","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/local-gene-editing-of-fibroblasts-in-tumors-reveals-a-new-cancer-associated-fibroblast-state","title":{"rendered":"Local gene editing of fibroblasts in tumors reveals a new cancer-associated fibroblast state"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/local-gene-editing-of-fibroblasts-in-tumors-reveals-a-new-cancer-associated-fibroblast-state.gif\"><\/a><\/p>\n<p>Nicholas F. Kuhn, Matthew F. Krummel et al. demonstrate how local gene editing of cancer-associated fibroblasts alters their cell state and, subsequently, the cellular tumor microenvironment.<\/p>\n<hr>\n<p>CAFs are prominent members of the TME. Kuhn et al. demonstrate how local gene editing of CAFs alters their cell state and, subsequently, the cellular TME.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nicholas F. Kuhn, Matthew F. Krummel et al. demonstrate how local gene editing of cancer-associated fibroblasts alters their cell state and, subsequently, the cellular tumor microenvironment. CAFs are prominent members of the TME. Kuhn et al. demonstrate how local gene editing of CAFs alters their cell state and, subsequently, the cellular TME.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11],"tags":[],"class_list":["post-234063","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234063","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=234063"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234063\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=234063"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=234063"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=234063"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}