{"id":234059,"date":"2026-03-25T18:21:53","date_gmt":"2026-03-25T23:21:53","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/fak-inhibition-in-ovarian-cancer-releases-omega-3-fatty-acids-to-program-cxcl13-producing-anti-tumor-resident-peritoneal-macrophages"},"modified":"2026-03-25T18:21:53","modified_gmt":"2026-03-25T23:21:53","slug":"fak-inhibition-in-ovarian-cancer-releases-omega-3-fatty-acids-to-program-cxcl13-producing-anti-tumor-resident-peritoneal-macrophages","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/fak-inhibition-in-ovarian-cancer-releases-omega-3-fatty-acids-to-program-cxcl13-producing-anti-tumor-resident-peritoneal-macrophages","title":{"rendered":"FAK inhibition in ovarian cancer releases omega-3 fatty acids to program CXCL13-producing anti-tumor resident peritoneal macrophages"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/fak-inhibition-in-ovarian-cancer-releases-omega-3-fatty-acids-to-program-cxcl13-producing-anti-tumor-resident-peritoneal-macrophages2.jpg\"><\/a><\/p>\n<p>FAK tyrosine kinase drives ovarian cancer tumor progression in part via effects on the tumor microenvironment. Chen et al. show that ovarian tumor FAK inhibition triggers release of omega-3 fatty acid-containing exosomes, impacting GATA6+ peritoneal macrophage anti-tumor reprogramming, <i>CXCL13<\/i> cytokine production, and anti-TIGIT immunotherapy.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>FAK tyrosine kinase drives ovarian cancer tumor progression in part via effects on the tumor microenvironment. Chen et al. show that ovarian tumor FAK inhibition triggers release of omega-3 fatty acid-containing exosomes, impacting GATA6+ peritoneal macrophage anti-tumor reprogramming, CXCL13 cytokine production, and anti-TIGIT immunotherapy.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-234059","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234059","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=234059"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234059\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=234059"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=234059"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=234059"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}