{"id":234007,"date":"2026-03-24T23:13:58","date_gmt":"2026-03-25T04:13:58","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/nonsense-mediated-mrna-decay-orchestrates-neuronal-migration-and-cortical-lamination-while-modulating-reelin-and-ciliary-gene-regulatory-networks"},"modified":"2026-03-24T23:13:58","modified_gmt":"2026-03-25T04:13:58","slug":"nonsense-mediated-mrna-decay-orchestrates-neuronal-migration-and-cortical-lamination-while-modulating-reelin-and-ciliary-gene-regulatory-networks","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/nonsense-mediated-mrna-decay-orchestrates-neuronal-migration-and-cortical-lamination-while-modulating-reelin-and-ciliary-gene-regulatory-networks","title":{"rendered":"Nonsense-mediated mRNA decay orchestrates neuronal migration and cortical lamination while modulating Reelin and ciliary gene regulatory networks"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/nonsense-mediated-mrna-decay-orchestrates-neuronal-migration-and-cortical-lamination-while-modulating-reelin-and-ciliary-gene-regulatory-networks2.jpg\"><\/a><\/p>\n<p>Lin et al. show that nonsense-mediated mRNA decay (NMD) is essential for neuronal migration and cortical lamination. UPF2 regulates expression of Reelin signaling and microtubule genes via Ino80 and represses ciliary gene Foxj1 to assure normal migration, revealing a key regulated RNA decay mechanism in brain development.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Lin et al. show that nonsense-mediated mRNA decay (NMD) is essential for neuronal migration and cortical lamination. UPF2 regulates expression of Reelin signaling and microtubule genes via Ino80 and represses ciliary gene Foxj1 to assure normal migration, revealing a key regulated RNA decay mechanism in brain development.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-234007","post","type-post","status-publish","format-standard","hentry","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234007","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=234007"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/234007\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=234007"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=234007"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=234007"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}