{"id":233983,"date":"2026-03-24T11:08:11","date_gmt":"2026-03-24T16:08:11","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/lysosomal-defects-are-emerging-as-a-feature-in-multiple-inflammatory-diseases"},"modified":"2026-03-24T11:08:11","modified_gmt":"2026-03-24T16:08:11","slug":"lysosomal-defects-are-emerging-as-a-feature-in-multiple-inflammatory-diseases","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/lysosomal-defects-are-emerging-as-a-feature-in-multiple-inflammatory-diseases","title":{"rendered":"Lysosomal defects are emerging as a feature in multiple inflammatory diseases"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/lysosomal-defects-are-emerging-as-a-feature-in-multiple-inflammatory-diseases2.jpg\"><\/a><\/p>\n<p>Barbara J. Vilen &amp; team now identify defective late endosomes and lysosomes (LELs) in patients with active lupus and show reduced LEL function promotes SLE through chronic PI3k activity and SHP-1\/SHIP-1 defects:<\/p>\n<p>The figure shows bone marrow-derived macrophages from lupus prone mice (MRL\/lpr) have decreased recruitment of pSHIP-1Y1022 (green) to the plasma membrane, indicated by cholera toxin-stained lipid rafts (blue), compared with control mice (B6).<\/p>\n<hr>\n<p>\n<sup>1<\/sup>Department of Microbiology and Immunology and.<\/p>\n<p><sup>2<\/sup>Division of Rheumatology, Allergy, and Immunology, Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, North Carolina, USA.<\/p>\n<p><sup>3<\/sup>Division of Rheumatology and Immunology, Duke University Medical Center, Durham, North Carolina, USA.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Barbara J. Vilen &amp; team now identify defective late endosomes and lysosomes (LELs) in patients with active lupus and show reduced LEL function promotes SLE through chronic PI3k activity and SHP-1\/SHIP-1 defects: The figure shows bone marrow-derived macrophages from lupus prone mice (MRL\/lpr) have decreased recruitment of pSHIP-1Y1022 (green) to the plasma membrane, indicated by [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1495],"tags":[],"class_list":["post-233983","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-health"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233983","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=233983"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233983\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=233983"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=233983"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=233983"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}