{"id":233978,"date":"2026-03-24T06:11:52","date_gmt":"2026-03-24T11:11:52","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/abstract-addressing-an-urgent-translational-need-for-patients-with-hereditary-cancer-syndromes-caused-by-mutations-in-mismatch-repair-mmr-genes"},"modified":"2026-03-24T06:11:52","modified_gmt":"2026-03-24T11:11:52","slug":"abstract-addressing-an-urgent-translational-need-for-patients-with-hereditary-cancer-syndromes-caused-by-mutations-in-mismatch-repair-mmr-genes","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/abstract-addressing-an-urgent-translational-need-for-patients-with-hereditary-cancer-syndromes-caused-by-mutations-in-mismatch-repair-mmr-genes","title":{"rendered":"Abstract: Addressing an urgent translational need for patients with hereditary cancer syndromes caused by mutations in mismatch repair (MMR) genes!"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/abstract116.jpg\"><\/a><\/p>\n<p><a href=\"https:\/\/doi.org\/10.1172\/JCI195189\">https:\/\/doi.org\/10.1172\/JCI195189<\/a> Dolores Hambardzumyan &amp; team develop mouse models of germline and somatic MMR-deficient high-grade gliomas, finding a role for MMR genes in tumor growth and temozolomide resistance, and presenting KL-50 as a therapeutic avenue.<\/p>\n<p>The figure demonstrates a potent anti-tumor effect from KL-50 treatment in glioblastoma models.<\/p>\n<hr>\n<p>\n<sup>1<\/sup>Departments of Oncological <i>Science<\/i>s and Neurosurgery, The Tisch Cancer Institute and.<\/p>\n<p><sup>2<\/sup>Department of Genetics and Genomic <i>Science<\/i>s, Icahn School of Medicine at Mount Sinai, New York, New York, USA.<\/p>\n<p><sup>3<\/sup>Departments of Systems Biology and Biomedical Informatics, Columbia University, New York, New York, USA.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>https:\/\/doi.org\/10.1172\/JCI195189 Dolores Hambardzumyan &amp; team develop mouse models of germline and somatic MMR-deficient high-grade gliomas, finding a role for MMR genes in tumor growth and temozolomide resistance, and presenting KL-50 as a therapeutic avenue. The figure demonstrates a potent anti-tumor effect from KL-50 treatment in glioblastoma models. 1Departments of Oncological Sciences and Neurosurgery, The Tisch [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-233978","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233978","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=233978"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233978\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=233978"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=233978"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=233978"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}