{"id":233920,"date":"2026-03-23T21:15:27","date_gmt":"2026-03-24T02:15:27","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/abstract-a-new-mouse-disease-model-for-parkinsonism-with-psychiatric-features-%f0%9f%91%87"},"modified":"2026-03-23T21:15:27","modified_gmt":"2026-03-24T02:15:27","slug":"abstract-a-new-mouse-disease-model-for-parkinsonism-with-psychiatric-features-%f0%9f%91%87","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/abstract-a-new-mouse-disease-model-for-parkinsonism-with-psychiatric-features-%f0%9f%91%87","title":{"rendered":"Abstract: A new mouse disease model for parkinsonism with psychiatric features \ud83d\udc47"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/abstract114.jpg\"><\/a><\/p>\n<p><a href=\"https:\/\/doi.org\/10.1172\/JCI169297\">https:\/\/doi.org\/10.1172\/JCI169297<\/a> Freja Herborg &amp; team explore the behavioral consequences and dopaminergic dysfunction that arise from patient-derived mutations in the dopamine transporter associated with parkinsonism and co-morbid neuropsychiatric disease, establishing a new mouse disease model.<\/p>\n<p>The images show striatal slices with decreased immunolabeling intensity of both DR1 and DR2 in DAT-I312F\/D421N+\/+ mice compared with WT mice.<\/p>\n<hr>\n<p>\n<sup>1<\/sup>Molecular <i>Neuropharmacology<\/i> and Genetics Laboratory, Department of <i>Neuroscience<\/i>, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<\/p>\n<p><sup>2<\/sup>CNS Research Group, Department of Pharmacology and Physiology, Department of <i>Neuroscience<\/i>s, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Quebec, Canada.<\/p>\n<p><sup>3<\/sup>Centre for <i>Neuroscience<\/i> and Stereology, Copenhagen University Hospital Bispebjerg-Frederiksberg, Copenhagen, Denmark.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>https:\/\/doi.org\/10.1172\/JCI169297 Freja Herborg &amp; team explore the behavioral consequences and dopaminergic dysfunction that arise from patient-derived mutations in the dopamine transporter associated with parkinsonism and co-morbid neuropsychiatric disease, establishing a new mouse disease model. The images show striatal slices with decreased immunolabeling intensity of both DR1 and DR2 in DAT-I312F\/D421N+\/+ mice compared with WT mice. [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,47],"tags":[],"class_list":["post-233920","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233920","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=233920"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233920\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=233920"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=233920"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=233920"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}