{"id":233855,"date":"2026-03-22T18:30:13","date_gmt":"2026-03-22T23:30:13","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/plasma-p-tau217-cutoffs-kidney-function-bmi-and-anemia"},"modified":"2026-03-22T18:30:13","modified_gmt":"2026-03-22T23:30:13","slug":"plasma-p-tau217-cutoffs-kidney-function-bmi-and-anemia","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/plasma-p-tau217-cutoffs-kidney-function-bmi-and-anemia","title":{"rendered":"Plasma p-tau217 Cutoffs, Kidney Function, BMI, and Anemia"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/plasma-p-tau217-cutoffs-kidney-function-bmi-and-anemia.png\"><\/a><\/p>\n<p>Biologically informed plasma pTau217 thresholds improved diagnostic accuracy for amyloid PET positivity in patients with CKD and anemia vs a standard single cutoff, supporting cost-efficient biomarker implementation in AlzheimerDisease screening.<\/p>\n<hr>\n<p>Question For plasma phosphorylated tau 217\u2013based amyloid-\u03b2 detection, does the strategy of using biological subgroup\u2013specific optimal single cutoffs or a double cutoff better optimize diagnostic accuracy and cost efficiency?<\/p>\n<p><strong>Findings<\/strong> This cohort study found that subgroup-specific optimal cutoffs improved accuracy over the standard single cutoff, especially in chronic kidney disease (CKD) and anemia. Compared with a double cutoff, the optimal cutoff had similar or better accuracy in CKD with lower cost, whereas a double cutoff was slightly better in underweight and anemia but created intermediates; in obesity, a double cutoff remained superior.<\/p>\n<p><strong>Meaning<\/strong> Biologically optimized cutoffs offer a balanced, cost-efficient default, particularly in CKD and anemia, while a double cutoff retains advantages in obesity.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Biologically informed plasma pTau217 thresholds improved diagnostic accuracy for amyloid PET positivity in patients with CKD and anemia vs a standard single cutoff, supporting cost-efficient biomarker implementation in AlzheimerDisease screening. Question For plasma phosphorylated tau 217\u2013based amyloid-\u03b2 detection, does the strategy of using biological subgroup\u2013specific optimal single cutoffs or a double cutoff better optimize diagnostic [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-233855","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233855","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=233855"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233855\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=233855"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=233855"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=233855"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}