{"id":233805,"date":"2026-03-21T23:11:14","date_gmt":"2026-03-22T04:11:14","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/insulin-and-adipocyte-irf4-promote-fat-retention-over-muscle-preservation-during-intermittent-fasting-in-obesity"},"modified":"2026-03-21T23:11:14","modified_gmt":"2026-03-22T04:11:14","slug":"insulin-and-adipocyte-irf4-promote-fat-retention-over-muscle-preservation-during-intermittent-fasting-in-obesity","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/insulin-and-adipocyte-irf4-promote-fat-retention-over-muscle-preservation-during-intermittent-fasting-in-obesity","title":{"rendered":"Insulin and adipocyte IRF4 promote fat retention over muscle preservation during intermittent fasting in obesity"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/insulin-and-adipocyte-irf4-promote-fat-retention-over-muscle-preservation-during-intermittent-fasting-in-obesity2.jpg\"><\/a><\/p>\n<p>Marko et al. show that elevated insulin in obese mice suppresses adipocyte IRF4, which governs fat versus muscle preservation during 5:2 intermittent fasting (IF) with or without caloric restriction. During an acute fast in humans, obesity and elevated insulin promoted lean mass loss in males but not females.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Marko et al. show that elevated insulin in obese mice suppresses adipocyte IRF4, which governs fat versus muscle preservation during 5:2 intermittent fasting (IF) with or without caloric restriction. During an acute fast in humans, obesity and elevated insulin promoted lean mass loss in males but not females.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-233805","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233805","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=233805"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233805\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=233805"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=233805"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=233805"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}