{"id":233744,"date":"2026-03-20T19:16:43","date_gmt":"2026-03-21T00:16:43","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/revealing-the-epigenetic-modulator-lysine-specific-histone-demethylase-1a-as-a-new-target-for-kidney-diseases"},"modified":"2026-03-20T19:16:43","modified_gmt":"2026-03-21T00:16:43","slug":"revealing-the-epigenetic-modulator-lysine-specific-histone-demethylase-1a-as-a-new-target-for-kidney-diseases","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/revealing-the-epigenetic-modulator-lysine-specific-histone-demethylase-1a-as-a-new-target-for-kidney-diseases","title":{"rendered":"Revealing the epigenetic modulator lysine-specific histone demethylase 1a as a new target for kidney diseases"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/revealing-the-epigenetic-modulator-lysine-specific-histone-demethylase-1a-as-a-new-target-for-kidney-diseases.jpg\"><\/a><\/p>\n<p><a href=\"https:\/\/doi.org\/10.1172\/jci.insight\">https:\/\/doi.org\/10.1172\/jci.insight<\/a>.<\/p>\n<p>Here, Tobias B. Huber &amp; team use a state-of-the-art, tour de force experimental design to show LSD1 regulates kidney development, and its dysfunction disrupts key kidney cells, leading to cyst formation in mouse and organoid models.<\/p>\n<p>The image shows severe structural changes in the adult mouse kidney with loss of KDM1a. Nephrology.<\/p>\n<hr>\n<p>\n<sup>4<\/sup>Faculty of Biology, Albert Ludwigs University of Freiburg, Freiburg, Germany.<\/p>\n<p><sup>5<\/sup>Institute of Medical Bioinformatics and Systems Medicine and.<\/p>\n<p><sup>6<\/sup>Institute of Surgical Pathology, Faculty of Medicine, Medical Center \u2014 University of Freiburg, Freiburg, Germany.<\/p>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2026\/03\/revealing-the-epigenetic-modulator-lysine-specific-histone-demethylase-1a-as-a-new-target-for-kidney-diseases\">Continue reading \u201cRevealing the epigenetic modulator lysine-specific histone demethylase 1a as a new target for kidney diseases\u201d | &gt;<\/a><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"<p>https:\/\/doi.org\/10.1172\/jci.insight. Here, Tobias B. Huber &amp; team use a state-of-the-art, tour de force experimental design to show LSD1 regulates kidney development, and its dysfunction disrupts key kidney cells, leading to cyst formation in mouse and organoid models. The image shows severe structural changes in the adult mouse kidney with loss of KDM1a. Nephrology. 4Faculty of [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-233744","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233744","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=233744"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233744\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=233744"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=233744"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=233744"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}