{"id":233656,"date":"2026-03-19T11:26:05","date_gmt":"2026-03-19T16:26:05","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/acsl4-associated-lipid-metabolism-is-a-distinct-therapeutic-vulnerability-in-kmt2a-rearranged-acute-myeloid-leukemia"},"modified":"2026-03-19T11:26:05","modified_gmt":"2026-03-19T16:26:05","slug":"acsl4-associated-lipid-metabolism-is-a-distinct-therapeutic-vulnerability-in-kmt2a-rearranged-acute-myeloid-leukemia","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/acsl4-associated-lipid-metabolism-is-a-distinct-therapeutic-vulnerability-in-kmt2a-rearranged-acute-myeloid-leukemia","title":{"rendered":"ACSL4-associated lipid metabolism is a distinct therapeutic vulnerability in KMT2A-rearranged acute myeloid leukemia"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/acsl4-associated-lipid-metabolism-is-a-distinct-therapeutic-vulnerability-in-kmt2a-rearranged-acute-myeloid-leukemia2.jpg\"><\/a><\/p>\n<p>Sch\u00e4fer et al. identify ACSL4 as a selective vulnerability in KMT2A-rearranged AML. ACSL4 knockdown impairs leukemic growth <i>in vitro<\/i> and <i>in vivo<\/i> by reprogramming lipid metabolism, which can be rescued by polyunsaturated fatty acids (PUFAs). A <i>KRADS12<\/i> signature derived from <i>ACSL4-<\/i>dependent cells is associated with poor patient survival.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sch\u00e4fer et al. identify ACSL4 as a selective vulnerability in KMT2A-rearranged AML. ACSL4 knockdown impairs leukemic growth in vitro and in vivo by reprogramming lipid metabolism, which can be rescued by polyunsaturated fatty acids (PUFAs). A KRADS12 signature derived from ACSL4-dependent cells is associated with poor patient survival.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-233656","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233656","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=233656"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233656\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=233656"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=233656"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=233656"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}