{"id":233652,"date":"2026-03-19T11:10:36","date_gmt":"2026-03-19T16:10:36","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2026\/03\/single-cell-analysis-identifies-retn-monocyte-derived-resistin-as-a-therapeutic-target-in-hepatitis-b-virus-related-acute-on-chronic-liver-failure"},"modified":"2026-03-19T11:10:36","modified_gmt":"2026-03-19T16:10:36","slug":"single-cell-analysis-identifies-retn-monocyte-derived-resistin-as-a-therapeutic-target-in-hepatitis-b-virus-related-acute-on-chronic-liver-failure","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2026\/03\/single-cell-analysis-identifies-retn-monocyte-derived-resistin-as-a-therapeutic-target-in-hepatitis-b-virus-related-acute-on-chronic-liver-failure","title":{"rendered":"Single-cell analysis identifies RETN+ monocyte-derived Resistin as a therapeutic target in hepatitis B virus-related acute-on-chronic liver failure"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/single-cell-analysis-identifies-retn-monocyte-derived-resistin-as-a-therapeutic-target-in-hepatitis-b-virus-related-acute-on-chronic-liver-failure.jpg\"><\/a><\/p>\n<p>GUTImage from the paper by Xu et al entitled.<\/p>\n<p>via.<\/p>\n<p>HepatitisB HBV<\/p>\n<hr>\n<p>Background Acute-on-chronic liver failure (ACLF) is characterised by intense systemic inflammation and high short-term mortality, yet effective targeted therapies are lacking.<\/p>\n<p>Objective To explore monocyte heterogeneity in HBV-related ACLF (HBV-ACLF) to identify specific subsets and associated therapeutic targets.<\/p>\n<p>Design Peripheral blood mononuclear cells from healthy controls (n=4), patients with acute decompensation (n=5), and patients with ACLF (n=9) underwent single-cell RNA sequencing (scRNA-seq). Findings were integrated with hepatic scRNA-seq, bulk transcriptomics, multiplex immunohistochemistry and in vitro functional assays. The in vivo roles of candidate targets were validated in two murine ACLF models.<\/p>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2026\/03\/single-cell-analysis-identifies-retn-monocyte-derived-resistin-as-a-therapeutic-target-in-hepatitis-b-virus-related-acute-on-chronic-liver-failure\">Continue reading \u201cSingle-cell analysis identifies RETN+ monocyte-derived Resistin as a therapeutic target in hepatitis B virus-related acute-on-chronic liver failure\u201d | &gt;<\/a><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"<p>GUTImage from the paper by Xu et al entitled. via. HepatitisB HBV Background Acute-on-chronic liver failure (ACLF) is characterised by intense systemic inflammation and high short-term mortality, yet effective targeted therapies are lacking. Objective To explore monocyte heterogeneity in HBV-related ACLF (HBV-ACLF) to identify specific subsets and associated therapeutic targets. Design Peripheral blood mononuclear cells [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,19],"tags":[],"class_list":["post-233652","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-chemistry"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233652","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=233652"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/233652\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=233652"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=233652"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=233652"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}